MBL(CycLex & CircuLex)/CircuLex Human PCSK9 ELISA Kit/CY-8079/96 assays,MBL,,MBL,CycLex & CircuLex,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：MBL(CycLex & CircuLex)/CircuLex Human PCSK9 ELISA Kit/CY-8079/96 assays

产品编号：CY-8079

市场价：¥9083.15

场地：美国(厂家直采)

产品分类：试剂盒>ELISA试剂盒>特色ELISA试剂盒>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$873.38

品牌： MBL

公司：MBL Inc

公司分类：

商品介绍

Components	Microplate,WashBuffer,DilutionBuffer,PCSK9Standard,HRPconjugatedDetectionAntibody,SubstrateReagent,StopSolution
Intendeduse	ThisKitisusedforthequantitativemeasurementofHumanPCSK9inserum,plasma,cellculturemediumandotherBIOLOGicalmedia.
Storagetemp.	4°C	Manufacturer	MBL
Animalspecies [GeneID]	Human
Sample	Serum,Plasma,Cellculturemedium,Otherbiologicalmedia
Measurementrange	0.16～10ng/mL
Sensitivity	0.154ng/mL～
Citations	NoguchiTetal.TheE32KvariantofPCSK9exacerbatesthephenotypeoffamilialhypercholesterolaemiabyincreasingPCSK9functionandconcentrationinthecirculation.Atherosclerosis210,166-172(2010)(PMID:20006333) CariouBetal.AssociationbetweenplasmaPCSK9andgamma-glutamyltransferaselevelsindiabeticpatients.Atherosclerosis211,700-702(2010)(PMID:20452593) CostetPetal.PlasmaPCSK9isincreasedbyFenofibrateandAtorvastatininanonadditivefashionindiabeticpatients.Atherosclerosis212,246-251(2010)(PMID:20619837) NoguchiTetal.Comparisonofeffectsofbezafibrateandfenofibrateoncirculatingproproteinconvertasesubtilisin/kexintype9andADIpocytokinelevelsindyslipidemicsubjectswithimpairedglucosetoleranceortype2diabetesmellitus:Resultsfromacrossoverstudy.Atherosclerosis217,165-70(2011)(PMID:21411093) MayneJetal.NovelLoss-of-FunctionPCSK9VariantIsAssociatedwithLowPlasmaLDLCholesterolinaFrench-CanadianFamilyandwithImpairedProcessingandSecretioninCellCulture.ClinChem.57,1415(2011)(PMID:21813713) VergèsBetal.LackofassociationbetweenplasmaPCSK9andLDL-apoB100catabolisminpatientswithuncontrolledtype2diabetes.Atherosclerosis.219,342-8(2011)(PMID:21889145) LenaPersson.StudiesonPCSK9intheregulationofcholesterolmetabolism.PublishedbyKarolinskaInstitutet.Stockholm2011 CariouBetal.ClinicalaspectsofPCSK9.Atherosclerosis.216,258-65(2011)(PMID:21596380) PerssonLetal.EndogenousEstrogensLowerPlasmaPCSK9andLDLCholesterolButNotLp(a)orBileAcidSynthesisinWomen.ArteriosclerThrombVascBiol.32,810-4(2011)(PMID:22207727) KawashiriMAetal.EfficacyandSafetyofCoadmiNISTrationofRosuvastatin,Ezetimibe,andColestimideinHeterozygousFamilialHypercholesterolemia.AmJCardiol.109,364-9(2011)(PMID:22112743) LindholmMWetal.PCSK9LNAAntisenseOligonucleotidesInduceSustainedReductionofLDLCholesterolinNonhumanPrimates.MolTher.20,376-81(2012)(PMID:22108858) CameronJetal.Serumlevelsofproproteinconvertasesubtilisin/kexintype9insubjectswithfamilialhypercholesterolemiaindicatethatproproteinconvertasesubtilisin/kexintype9isclearedfromplasmabylow-densitylipoproteinreceptor_independentpathways.TranslationalResearch.160,125-30(2012)(PMID:22683370) HuijgenRetal.PlasmalevelsofproproteinconvertasesubtilisinKexintype9(PCSK9)andphenotypicvariABIlityinfamilialhypercholesterolemia.JLipidRes.53,979-83(2012)(PMID:22375030) CariouBetal.PlasmaPCSK9concentrationsduringanoralfatloadandaftershorttermhigh-fat,high-fathigh-proteinandhigh-fructosediets.NutrMetab.10,4(2013)(PMID:23298392) LeeCJetal.Associationofserumproproteinconvertasesubtilisin/kexintype9withcarotidintimamediathicknessinhypertensivesubjects.Metabolism.62,845-50(2013)(PMID:23380568) LeBrasMetal.PlasmaPCSK9isalatebioMarkerofseverityinpatientswithseveretraumainjury.JClinEndocrinolMetab.98,E732-6(2013)(PMID:23450051) MayneJetal.DifferentialeffectsofPCSK9lossoffunctionvariantsonserumlipidandPCSK9levelsinCaucasianandAfricanCanadianpopulations.LipidsHealthDis.12,70(2013)(PMID:23663650) PeticcaPetal.HumanSerumPCSK9IsElevatedatParturitioninComparisontoNonpregnantSubjectsWhileSerumPCSK9fromUmbilicalCordBloodisLowerComparedtoMaternalBlood.ISRNEndocrinol.2013,341632(2013)(PMID:23862071) TremblayAJetal.Short-term,high-fatdietincreasestheexpressionofkeyintestinalgenesinvolvedinlipoproteinmetabolisminhealthymen.AmJClinNutr.98,32-41(2013)(PMID:23719552) ConwayVetal.Impactofbuttermilkconsumptiononplasmalipidsandsurrogatemarkersofcholesterolhomeostasisinmenandwomen.NutrMetabCardiovascDis.23,1255-62(2013)(PMID:23786821) LambertGetal.ElevatedplasmaPCSK9levelisequallydetrimentalforpatientswithnonfamilialhypercholesterolemiaandheterozygousfamilialhypercholesterolemia,irrespectiveoflow-densitylipoproteinreceptordefects.JAmCollCardiol.63,2365-73(2014)(PMID:24632287) WernerCetal.Riskpredictionwithproproteinconvertasesubtilisin/kexintype9(PCSK9)inpatientswithstablecoronarydiseaseonstatintreatment.VasculPharmacol.62,94-102(2014)(PMID:24685817) AbujradHetal.ChronickidneydiseaseonhemodialysisisassociatedwithdecreasedserumPCSK9levels.Atherosclerosis.233,123-9(2014)(PMID:24529132) JiaYJetal.Short-andlong-termeffectsofXuezhikang(),anextractofcholestin,onserumproproteinconvertasesubtilisin/kexintype9levels.ChinJIntegrMed.(2014)(PMID:24993334) BondeYetal.ThyroidhormonereducesPCSK9andstimulatesbileacidsynthesisinhumans.JLipidRes.55,2408-15(2014)(PMID:25172631) MbikayMetal.Quercetin-3-glucosideincreaseslow-densitylipoproteinreceptor(LDLR)expression,attenuatesproproteinconvertasesubtilisin/kexin9(PCSK9)secretion,andstimulatesLDLuptakebyHuh7humanhepatocytesinculture.FEBSOpenBio.4,755-62(2014)(PMID:25349780) IggmanDetal.Roleofdietaryfatsinmodulatingcardiometabolicriskduringmoderateweightgain:arandomizeddouble-blindoverfeedingtrial(LIPOGAINstudy).JAmHeartAssoc.3,e001095(2014)(PMID:25319187) XuRXetal.RelationofplasmaPCSK9levelstolipoproteinsubfractionsinpatientswithstablecoronaryarterydisease.LipidsHealthDis.13,188(2014)(PMID:25496400) GhoshMetal.InfluenceofphysiologicalchangesinendogenousestrogenoncirculatingPCSK9andLDLcholesterol.JLipidRes.56,463-9(2015)(PMID:25535288) XuRXetal.ImpactsofezetimibeonPCSK9inrats:studyontheexpressionindifferentorgansandthepotentialmechanisms.JTranslMed.13,87(2015)(PMID:25889684) StarrAEetal.β-Estradiolresultsinaproproteinconvertasesubtilisin/kexintype9-dependentincreaseinlow-densitylipoproteinreceptorlevelsinhumanhepaticHuH7cells.FEBSJ.282,2682-96(2015)(PMID:25913303) RosqvistFetal.Potentialroleofmilkfatglobulemembraneinmodulatingplasmalipoproteins,geneexpression,andcholesterolmetabolisminhumans:arandomizedstudy.AmJClinNutr.102,20-30(2015)(PMID:26016870) ButkinareeCetal.AmyloidPrecursor-likeProtein2andSortilinDoNotRegulatethePCSK9Convertase-mediatedLowDensityLipoproteinReceptorDegradationbutInteractwithEachOther.JBiolChem.290,18609-20(2015)(PMID:26085104) vanPelgeestEPetal.Antisense-mediatedreductionofproproteinconvertasesubtilisin/kexintype9(PCSK9):afirst-in-humanrandomized,placebo-controlledtrial.BrJClinPharmacol.80,1350-61(2015)(PMID:26261033) WassefHetal.TheapoB-to-PCSK9ratio:Anewindexformetabolicriskinhumans.JClinLipidol.9,664-75(2015)(PMID:26350813) Si-TayebKetal.Urine-sample-derivedhumaninducedpluripotentstemcellsasamodeltostudyPCSK9-mediatedautosomaldominanthypercholesterolemia.DisModelMech.9,81-90(2016)(PMID:26586530) RogacevKSetal.PCSK9PlasmaConcentrationsAreIndependentofGFRandDoNotPredictCardiovascularEventsinPatientswithDecreasedGFR.PLoSOne11,e0146920(2016)(PMID:26799206) MiasanAetal.EffectsofLDLReceptorModulationonLymphaticFunction.SciRep.6,27862(2016)(PMID:27279328) VlachopopulosCetal.Predictionofcardiovasculareventswithlevelsofproproteinconvertasesubtilisin/kexintype9:Asystematicreviewandmeta-analysis.Atherosclerosis.252,50-60(2016)(PMID:27501130) LiSetal.Novelcirculatinglipidmeasurementsforcurrentdyslipidemiasinnon-treatedpatientsundergoingcoronaryangiography:PCSK9,apoC3andsdLDL-C.Oncotarget8,12333-12341(2017)(PMID:27713142) NavareseEPetal.AssociationofPCSK9withplateletreactivityinpatientswithacutecoronarysyndrometreatedwithprasugrelorticagrelor:ThePCSK9-REACTstudy.IntJCardiol.227,644-649(2017)(PMID:27810295) SuzukiYetal.BiodegradablelipidnanoparticlesinduceaprolongedRNAinterference-mediatedproteinknockdownandshowrapidhepaticclearanceinmiceandnonhumanprimates.IntJPharm.519,34-43(2017)(PMID:28089936) LiSetal.Novelandtraditionallipid-relatedbiomarkersandtheircombinationsinpredictingcoronaryseverity.SciRep.7,360(2017)(PMID:28336922) HyrinaAetal.Treatment-InducedViralCureofHepatitisCVirus-InfectedPatientsInvolvesaDynamicInterplayamongthreeImportantMolecularPlayersinLipidHomeostasis:CirculatingmicroRNA(miR)-24,miR-223,andProproteinConvertaseSubtilisin/KexinType9.EBioMedicine.23,68-78(2017)(PMID:28864162) BlanchardCetal.Roux-en-Ygastricbypassreducesplasmacholesterolindiet-inducedobesemicebyaffectingtrans-intestinalcholesterolexcretionandintestinalcholesterolabsorption.IntJObes.(2017)Inpress.(PMID:29135972)
Productcategory	Researcharea Metabolism Drugdiscovery

品牌介绍

MBL

MBL, 成立于1969年，是日本第一家抗体生产商。公司早期致力于研究生产血浆蛋白质抗体，是抗体研究、发展和生产的先锋者。现在，公司提供3000多种细胞骨架、致癌基因产品和信号转导蛋白质抗体。1975年，MBL成为日本首家血浆蛋白质的诊断剂的生产商，之后，公司就致力于开发、生产免疫诊断试剂，特别是自身免疫性疾病方面的诊断试剂。公司的研发能力在该领域中得到了极高的评价。

MBL was founded in 1976 in Minneapolis, MN. It is a wholly owned subsidiary of TECHNE Corporation (a holding company with no employees). The stock is traded publicly on NASDAQ’s National Market System under the “TECH” symbol. TECHNE has two operating subsidiaries: Research & Diagnostics Systems, Inc. (MBL) and MBL Europe Ltd. MBL has two operating divisions: Biotechnology, which manufactures reagents primarily for the research market, and Hematology.

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